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Inhibitors of CYP3A4 like cimetidine and erythromycin are prone to cut down sildenafil clearance. CYP3A4 inducers such as rifampicin may reduce the plasma concentrations of sildenafil. Symptomatic hypotension when utilized with α-blockers. Plasma concentrations are increased by ritonavir.

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The safety and efficacy of sildenafil indicated for managing PAH in a lady in the course of labor and delivery haven't been examined .

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